It is not difficult to take up a new career in midlife.

人到中年开始新的事业并不难。

《牛津词典》

He left a career in teaching to take up a position with the NEH.

他放弃了教职，以便在国家人文基金会任职。

《柯林斯英汉双解大词典》

For instance, if you're in a career that you don't like, every step you take up the ladder is just taking you further and further in the wrong direction.

比如说，如果你在从事一种你并不喜欢的事业，你一步一步顺着梯子向上爬，不过是让你在错误的方向走的越来越远。

youdao

He was a poet who died before he could take up his career, and it's not unlikely that -- he wasn't married - that he was also a poet who died while he was still a virgin.

他是个事业还没起步就死了的诗人，并非不可能--金还没结婚,-他还是个未失童真就死了的诗人。

耶鲁公开课 - 弥尔顿课程节选

There has been speculation that he may now take up a career as a television pundit, but Vaughan said he had not yet received any offers to join the ranks of ex-England players working in the media.

BBC: Ashes hero Vaughan calls it quits

However, at what seemed to be the tipping point of his career at the big bank, he surprised everyone by quitting his job to take up a position in a small Southeast Asian bank.

FORBES: To Continue Growing, Quit The Big Job